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. Author manuscript; available in PMC: 2021 Jan 9.
Published in final edited form as: Cell. 2020 Jan 9;180(1):50–63.e12. doi: 10.1016/j.cell.2019.12.016

Figure 1. Epithelial Cell- and Immune Cell-Derived IL-18 Does Not Protect against Enteric S.t. Infection.

Figure 1.

(A) Weight loss of Il18f/f (n = 15) or Il18f/fFlk1+ (n = 7) mice infected with S.t. Data represent mean ± SEM; unpaired t test was used for statistical analysis. Data represent two independent experiments combined.

(B and C) S.t. colony-forming unit (CFU)/g of (B) cecum, (C) spleen, and liver from Il18f/f or Il18f/fFlk1+ mice 4 days post-infection. Data represent mean ± SEM; Mann-Whitney test was used for statistical analysis. Each dot represents one mouse. Data represent two independent experiments combined.

(D) Weight loss of Il18f/f (n = 7) or Il18f/fVil1+ (n = 8) mice infected with S.t. Data represent mean ± SEM; unpaired t test was used for statistical analysis. Data represent two independent experiments combined from three total independent experiments.

(E and F) S.t. CFU/g of (E) cecum, (F) spleen, and liver from Il18f/f or Il18f/fVil1+ mice 4 days post-infection. Data represent mean ± SEM; Mann-Whitney test was used for statistical analysis. Each dot represents one mouse. Data represent two independent experiments combined from three total independent experiments.