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. 2020 Jun 30;11:663. doi: 10.3389/fgene.2020.00663

FIGURE 1.

FIGURE 1

(A) The top twenty genes that were most frequently mutated in gastric cancer (GC) are displayed based on their mutation frequency in a waterfall plot. The corresponding gene mutation patterns and clinical status (ethnicity, grade, and gender) of the stomach adenocarcinoma (STAD) cohort are shown in the comment bar. (B) Kaplan–Meier survival analysis stratified by MUC16 mutation status. (C) Association of tumor mutation burden (TMB) with MUC16 mutation status. (D) Survival curves show that the low-TMB group had poorer overall survival (OS) than the high-TMB group. (E) Differences in stromal scores between low- and high-TMB groups. (F) Differences in immune scores between low- and high-TMB groups. (G) Differences in tumor purity between low- and high-TMB groups. (H) Kaplan–Meier survival analysis divided by stromal scores. (I) Kaplan–Meier survival analysis divided by immune scores. (J) Kaplan–Meier survival analysis divided by ESTIMATE scores. ****P < 0.0001; **P < 0.01.