Figure 3.

The protective roles of Ad5-G-Gn in RABV and SFTSV infection. Groups of C57/BL6 mice (n = 18) were immunized with 10⁸ GFU of Ad5-G-Gn, Ad5-GFP, or mocked by the i.m. route. At 28 dpi, viral challenge tests were carried out. (A) Survival of mice challenged with lethal RABV. At 28 dpi, mice (n = 8) were challenged with 100 MLD₅₀ of HuNPB3 by the i.m. route and survival of mice were observed for 21 days. (B) SFTS viral load in spleens. At 28 dpi, mice (n = 10) were challenged with 1 × 10⁶ TCID₅₀ of SFTSV (JS2011-013-1) by the i.m. route. SFTS viral load in spleens was detected at 3 and 7 days after viral challenge (^**p < 0.01; ^***p < 0.001).