Figure 1.
B-ALL engraftment and progression in immunocompetent recipient mice. (A) 2-photon intravital images of the calvarial bone marrow on day 1, 3, and 4 post-injection (p.i.) of 2.5 × 105 B-ALL in C57BL6 mice. The blood was visualized using i.v. injection of BSA-AF647. The white arrows point to individual leukemia cells on day 1 p.i. (B) Leukemia tissue invasion index at different time points post-injection. B-ALL cells were injected in C57BL6 mice then tissues were collected and imaged (3 mice per time point day 5, 7, and 13 p.i.).