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. 2020 Jun 30;10:991. doi: 10.3389/fonc.2020.00991

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Copyright © 2020 Rytelewski, Harutyunyan, Baran, Mallampati, Zal, Cavazos, Butler, Konoplev, El Khatib, Plunkett, Marszalek, Andreeff, Zal and Konopleva.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evaluation of the effect of Complex I inhibitor (OxPhos_i) on BM hypoxia using pimonidazole IHC. (A,C) representative IHC of skull section of untreated leukemic mouse and (B,D) IHC of skull section of IACS-010759 treated mouse; (E,F) H&E on corresponding adjacent sections. (G) Semi quantitative analysis of pimonidazole IHC intensity by Histo-score (H-score) for skull section of individual leukemic mice on day 15 p.i. (H) Average pimonidazole IHC intensity for 3 mice in each group day 15 p.i. ****p < 0.0001.