Fig. 2 |. Fitness scores of α-synuclein point mutants.

a, Fitness scores (defined as the slope of the line describing change in log-transformed variant frequencies over time) for expression of α-synuclein point mutants in yeast. b, Average fitness scores of mutants with hydrophobic (W, Y, F, L, I, V, M, C, A), polar (S, T, N, Q, H, R, K, D, E), or proline residues. c, Fitness score averaged over an 11-residue window. Experiments were performed four independent times with similar results (Supplementary Fig. 1) and the average of all four replicates is shown.