Table 1.
Baseline Characteristics.
| Characteristics | Patient 1 | Patient 2 | Patient 3 | Patient 4 |
|---|---|---|---|---|
| Demographics characteristics | ||||
| Age (years) | 51 | 70 | 54 | 48 |
| Gender | M | F | M | M |
| Initial Findings | ||||
| Medical History | HTN, HLD, CAD | No PMH | HTN | HLD |
| Respiratory Symptoms | Fever, cough, myalgias, dyspnea | Fever, cough, hypoxia | Shortness of breath, cough, hypoxia | None |
| Neurological Symptoms | L hemiplegia | L hemiplegia | Coma | Aphasia, R hemiplegia |
| Admission Chest X-ray Findings | Diffuse bilateral airspace opacities | B/L consolidations and ground glass opacities | B/L patchy airspace opacities and left lower lobe consolidation | Normal lung fields bilaterally |
| Days from disease onset to thrombotic event | 5 | 3 | 11 | 1 |
| Findings on ICU Admission | ||||
| Disease Severity | Critical | Critical | Critical | Moderate |
| Laboratory findings | ||||
| White Cell count (per mm3) | 5.8 | 17.7 | 14.6 | 10.3 |
| Platelet count (per mm3) | 273 | 483 | 372 | 237 |
| Hemoglobin (g/L) | 11.51 | 12 | 14.4 | 13.3 |
| Prothrombin time (s) | 15.7 | 14.6 | 11.8 | 12.2 |
| Activated partial thromboplastin (s) | 36 | 43 | 25 | 29 |
| Fibrinogen (g/L) | 719 | 970 | 429 | 243 |
| Fibrin degradation products (mg/L) | >20 | >20 | Not obtained | Not obtained |
| D-dimer (mg/L) | 2,476 | 11,559 | 7,873 | 6383 |
| Serum ferritin (μg/L) | 1,085 | 3500 | 508 | 270 |
| Procalcitonin (ng/ml) | 6.23 | 0.26 | 0.09 | 0.05 |
| High-sensitivity C-reactive protein (mg/L) | 21.60 | 39.90 | 3.90 | 0.30 |
| Lupus Anticoagulant (s) | ||||
| dRVVT Screen | 60.8 | 54.5 | 61.4 | 31 |
| dRVVT Mix | 42.5 | 46.2 | 45.4 | NA |
| dRVVT Confirm | 37.1 | 33.2 | 37.1 | 25.6 |
| dRVVT Normalized Ratio | 1.3 | 1.4 | 1.4 | 1.2 |
| Interleukin 6 | 185.33 | 458.41 | 24.53 | 9.6 |
| Glycated Hemoglobin (%) | 7% | 5.5 | 6.8 | 5.4 |
| Low-density lipoprotein (mg/dL) | <40 | 63 | 69 | 166 |
| Stroke Characteristics | ||||
| NIHSS | 20 | 28 | NA | 31 |
| CT Head on hospital day 2 | Large right MCA infarct in temporal, posterior frontal and parietal lobes | Large right MCA and ACA infarct | Bilateral thalamic and basal ganglia infarcts with hydrocephalus and cerebral edema | Mild attenuation of L insular ribbon |
| Vessel Imaging (CTA, CTV) | R ICA occlusion | R M2 occlusion | filling defects in the vein of Galen, straight sinus, bilateral internal cerebral veins and right basal vein of Rosenthal | L M1 occlusion |
| Treatment | Mechanical Thrombectomy | Mechanical Thrombectomy, hemicraniectomy | EVD, hypertonic therapy | TPA, Mechanical Thrombectomy |
| TICI Score | 0 to 2B | 0 to 2A | NA | 0 to 3 |
M = Male, F = Female, MCA = Middle cerebral artery, ACA = Anterior cerebral artery.