. Author manuscript; available in PMC: 2020 Sep 1.

Published in final edited form as: Anesth Analg. 2019 Sep;129(3):762–773. doi: 10.1213/ANE.0000000000004234

Table 3.

Fibrinolysis Phenotypes

Phenotype	VHA Clot Degradation (LY30, ML)	PAP	d-Dimer	t-PA Antigen	t-PA Activity	PAI-1 Antigen	PAI-1 Activity
Hyperfibrinolysis	⇑	⇑⇑	⇑⇑	⇑⇑	⇑⇑	⇔⇓	⇓⇓
Acute shutdown	⇓	⇑⇑	⇑⇑	⇑	⇔⇓	⇔	⇓
Hypofibrinolysis	⇓	⇔	⇔	⇔	⇓	⇔	⇑
Physiologic	⇔	⇑	⇑	⇔⇑	⇔	⇔	⇔
Acquired shutdown	⇓	⇑	⇑	⇓	⇓	⇑⇑	⇑⇑
Persistent shutdown^a	⇓	⇔	⇔	⇓	⇓	⇑	⇑

Abbreviations: LY30, lysis at 30 min; ML, maximal lysis; PAI-1, plasminogen activator inhibitor 1; PAP plasmin–antiplasmin levels; t-PA, tissue plasminogen activator; VHA, viscoelastic hemostatic assays.

Greater than or equal to 24 h from injury.