Table 2:
Associations of time to SLICC/ ACR Damage Index items and smoking status in all cohort patients and separately in African- American and Caucasian patients (stratification by ethnicity)
| All | African American | Caucasian | |||||||
|---|---|---|---|---|---|---|---|---|---|
| # of events | HR1 (95% CI) | p-value | # of events | HR2 (95% CI) | p-value | # of events | HR2 (95% CI) | p-value | |
| Any cataract ever | 420 | 1 (0.82,1.22) | 0.9948 | 172 | 1.3 (0.95,1.78) | 0.0979 | 229 | 0.77 (0.59,1.02) | 0.0652 |
| Retinal change OR optic atrophy | 103 | 0.91 (0.6,1.36) | 0.6389 | 42 | 0.85 (0.45,1.61) | 0.6133 | 58 | 0.86 (0.5,1.49) | 0.5988 |
| Cognitive impairment OR major psychosis | 135 | 1.09 (0.76,1.56) | 0.6301 | 51 | 0.69 (0.38,1.28) | 0.2434 | 78 | 1.22 (0.77,1.92) | 0.4055 |
| Seizures requiring therapy for 6 months | 62 | 0.93 (0.54,1.62) | 0.8047 | 24 | 0.65 (0.26,1.66) | 0.3700 | 32 | 0.98 (0.46,2.06) | 0.9505 |
| Cerebral vascular accident ever OR resection | 186 | 1.08 (0.8,1.47) | 0.6012 | 85 | 1.08 (0.69,1.7) | 0.7219 | 94 | 1.02 (0.66,1.56) | 0.9427 |
| Cranial OR peripheral neuropathy | 186 | 0.85 (0.63,1.16) | 0.3046 | 71 | 0.49 (0.29,0.83) | 0.0081 | 109 | 1.24 (0.84,1.83) | 0.2749 |
| Transverse myelitis | 16 | 0.51 (0.14,1.84) | 0.3030 | 7 | 0.64 (0.12,3.59) | 0.6158 | 8 | 0.38 (0.05,3.07) | 0.3609 |
| Estimated or measured GFR < 50% | 447 | 0.94 (0.77,1.15) | 0.5640 | 220 | 1.03 (0.78,1.36) | 0.8484 | 193 | 0.82 (0.6,1.1) | 0.1821 |
| Proteinuria 3.5g/24hrs | 179 | 0.95 (0.68,1.31) | 0.7379 | 103 | 1.11 (0.72,1.7) | 0.6390 | 53 | 0.79 (0.43,1.45) | 0.4470 |
| End-stage renal disease | 120 | 0.72 (0.48,1.07) | 0.1060 | 74 | 0.82 (0.49,1.35) | 0.4285 | 37 | 0.57 (0.26,1.24) | 0.1550 |
| Pulmonary hypertension | 190 | 1.19 (0.89,1.6) | 0.2485 | 107 | 1.33 (0.89,1.98) | 0.1593 | 76 | 0.95 (0.59,1.5) | 0.8119 |
| Pulmonary fibrosis | 178 | 0.77 (0.56,1.06) | 0.1035 | 89 | 0.54 (0.34,0.86) | 0.0094 | 81 | 1.04 (0.66,1.63) | 0.8681 |
| Shrinking lung | 9 | 0.34 (0.04,2.8) | 0.3192 | 3 | N/C | N/C | 6 | 0.52 (0.06,4.52) | 0.5529 |
| Pleural fibrosis | 68 | 0.95 (0.58,1.58) | 0.8563 | 31 | 0.52 (0.24,1.15) | 0.1089 | 33 | 1.35 (0.67,2.72) | 0.3976 |
| Pulmonary infarction OR resection | 8 | 0.66 (0.13,3.4) | 0.6209 | 1 | N/C | N/C | 7 | 0.77 (0.14,4.11) | 0.7567 |
| Angina OR coronary artery bypass | 88 | 1.55 (1,2.39) | 0.0498 | 29 | 1.41 (0.65,3.04) | 0.3870 | 55 | 1.84 (1.06,3.19) | 0.0309 |
| Myocardial infarction ever | 99 | 1.77 (1.17,2.67) | 0.0070 | 43 | 1.52 (0.8,2.87) | 0.2011 | 50 | 2.05 (1.16,3.63) | 0.0138 |
| Cardiomyopathy | 80 | 1.37 (0.86,2.17) | 0.1839 | 49 | 1.3 (0.72,2.36) | 0.3891 | 27 | 1.45 (0.67,3.13) | 0.3477 |
| Valvular disease | 59 | 0.87 (0.51,1.5) | 0.6245 | 24 | 1.4 (0.6,3.25) | 0.4406 | 33 | 0.62 (0.29,1.31) | 0.2114 |
| Pericarditis>6 months, OR pericardiectomy | 30 | 0.85 (0.38,1.89) | 0.6901 | 20 | 0.41 (0.13,1.29) | 0.1287 | 9 | 3.15 (0.75,13.14) | 0.1158 |
| Claudication x6 months | 35 | 2.87 (1.38,5.97) | 0.0047 | 16 | 3.36 (1.03,10.96) | 0.0440 | 19 | 2.54 (0.99,6.55) | 0.0529 |
| Minor tissue loss (pulp space) | 15 | 0.64 (0.19,2.12) | 0.4662 | 9 | 0.73 (0.17,3.22) | 0.6826 | 5 | 0.46 (0.05,4.28) | 0.4975 |
| Significant tissue loss ever | 21 | 1.44 (0.59,3.53) | 0.4220 | 10 | 1.6 (0.42,6.05) | 0.4881 | 10 | 1.4 (0.39,4.99) | 0.6024 |
| Venous thrombosis with swelling, ulceration, OR venous stasis | 66 | 0.54 (0.31,0.94) | 0.0294 | 26 | 0.52 (0.22,1.24) | 0.1393 | 40 | 0.55 (0.27,1.13) | 0.1029 |
| Infarction or resection of bowel | 209 | 1.06 (0.8,1.42) | 0.6694 | 76 | 0.74 (0.45,1.22) | 0.2370 | 126 | 1.22 (0.85,1.76) | 0.2790 |
| Mesenteric insufficiency | 8 | 0.68 (0.16,2.98) | 0.6083 | 5 | 1.09 (0.17,7.02) | 0.9253 | 3 | 0.54 (0.05,6.2) | 0.6241 |
| Chronic peritonitis | 7 | 0.26 (0.03,2.29) | 0.2262 | 4 | N/C | N/C | 3 | 1.11 (0.1,12.53) | 0.9328 |
| Stricture OR upper gastrointestinal tract surgery ever | 16 | 1.08 (0.39,3.04) | 0.8772 | 9 | 1.54 (0.39,6.17) | 0.5405 | 7 | 0.67 (0.12,3.59) | 0.6395 |
| Pancreatitis | 9 | 5.47 (1.09,27.42) | 0.0386 | 2 | N/C | N/C | 7 | 3.93 (0.73,21.29) | 0.1124 |
| Muscle atrophy or weakness | 47 | 1.42 (0.78,2.6) | 0.2489 | 26 | 0.73 (0.31,1.72) | 0.4737 | 20 | 2.69 (1.08,6.72) | 0.0337 |
| Deforming or erosive arthritis | 232 | 0.83 (0.63,1.09) | 0.1759 | 130 | 0.76 (0.53,1.11) | 0.1562 | 85 | 1.05 (0.68,1.63) | 0.8283 |
| Osteoporosis with fracture or vertebral collapse | 312 | 0.9 (0.72,1.14) | 0.4004 | 93 | 0.64 (0.41,0.99) | 0.0454 | 210 | 1 (0.76,1.32) | 0.9978 |
| Avascular necrosis | 198 | 1.24 (0.92,1.67) | 0.1636 | 110 | 1.41 (0.94,2.11) | 0.0991 | 73 | 0.95 (0.58,1.56) | 0.8411 |
| Osteomyelitis | 19 | 1.21 (0.47,3.08) | 0.6946 | 7 | 0.96 (0.19,4.8) | 0.9555 | 12 | 1.48 (0.47,4.73) | 0.5042 |
| Ruptured tendon | 74 | 1.25 (0.77,2.01) | 0.3645 | 29 | 1.66 (0.75,3.69) | 0.2137 | 41 | 0.72 (0.37,1.43) | 0.3511 |
| Scarring chronic alopecia | 65 | 1.6 (0.96,2.67) | 0.0713 | 53 | 1.51 (0.85,2.66) | 0.1561 | 11 | 2.57 (0.73,9.11) | 0.1432 |
| Extensive scarring or panniculum other than scalp and pulp space | 37 | 2.53 (1.26,5.07) | 0.0092 | 27 | 2.92 (1.27,6.76) | 0.0120 | 10 | 1.82 (0.5,6.59) | 0.3596 |
| Skin ulceration (not due to thrombosis) for more than 6 months | 25 | 2.7 (1.15,6.35) | 0.0225 | 13 | 3.17 (0.91,10.98) | 0.0690 | 12 | 2.31 (0.7,7.57) | 0.1681 |
| Premature gonadal failure | 67 | 1.45 (0.87,2.41) | 0.1561 | 26 | 1.13 (0.49,2.63) | 0.7719 | 32 | 1.89 (0.92,3.89) | 0.0837 |
| Diabetes | 134 | 1.07 (0.75,1.53) | 0.6926 | 79 | 1.27 (0.8,2.01) | 0.3175 | 50 | 0.71 (0.39,1.3) | 0.2678 |
| Malignancy (exclude dysplasia) | 245 | 0.99 (0.76,1.29) | 0.9326 | 92 | 0.9 (0.59,1.39) | 0.6392 | 148 | 1 (0.71,1.4) | 0.9902 |
1
Adjusted for sex, race, age at diagnosis, years of education
2
Adjusted for sex, age at diagnosis, years of education