Table 5:
A comparison of neuropathy outcome measurements between lean controls and obese patients with and without neuropathy
| Variable | Lean* (n=45) | Obese without neuropathy (n=110) | P-Value | Obese with neuropathy (n=28) | P-Value |
|---|---|---|---|---|---|
| IENFD leg (fibers/mm) | 13.7 (6.3) | 9.3 (6.9) | <0.01 | 3.0 (3.3) | <0.01 |
| IENFD thigh (fibers/mm) | 26.4 (7.6) | 15.1 (8.2) | <0.01 | 12.2 (6.6) | 0.06 |
| Sural amplitude (uV) | 20.7 (9.0) | 11.3 (6.7) | <0.01 | 5.8 (4.7) | <0.01 |
| Sural PL (ms) | 4.0 (0.4) | 3.8 (0.5) | 0.01 | 4.1 (0.5) | 0.03 |
| Sural NR | 0 (0.0%) | 5 (4.6%) | 5 (17.9%) | ||
| Peroneal amplitude (mV) | 5.6 (2.3) | 5.4 (2.7) | 0.76 | 2.9 (2.3) | <0.01 |
| Peroneal DML (ms) | 5.0 (1.0) | 4.5 (0.8) | <0.01 | 5.0 (1.0) | 0.05 |
| Peroneal CV (m/s) | 46.1 (4.8) | 46.6 (5.2) | 0.61 | 40.5 (4.2) | <0.01 |
| Peroneal NR | 0 (0.0%) | 2 (1.8%) | 4 (14.3%) | ||
| Peroneal F response (ms) | 49.4 (5.4) | 48.6 (5.3) | 0.44 | 52.8 (7.4) | 0.02 |
| Peroneal F NR | 1 (2.2%) | 7 (6.4%) | 4 (14.3%) | ||
| Tibial amplitude (mV) | 12.9 (5.4) | 9.6 (4.8) | <0.01 | 4.9 (4) | <0.01 |
| Tibial DML (ms) | 4.9 (0.8) | 4.7 (0.9) | 0.36 | 5.3 (0.9) | 0.01 |
| Tibial NR | 0 (0.0%) | 1 (1.0%) | 3 (10.7%) | ||
| Tibial F response (ms) | 49.7 (4.8) | 50.4 (5.4) | 0.43 | 55.7 (7.1) | <0.01 |
| Tibial F NR | 1 (2.2%) | 1 (1.0%) | 3 (10.7%) | ||
| UENS | 0.7 (1.8) | 1.6 (2.9) | 0.02 | 11.9 (6.7) | <0.01 |
| MNSI Questionnaire | 0.5 (0.9) | 2.5 (2.3) | <0.01 | 6.5 (2.6) | <0.01 |
| MNSI Examination | 0.2 (0.7) | 0.7 (1.0) | <0.01 | 2.4 (1.7) | <0.01 |
| Neurothesiometer (um) | 14.0 (19.0) | 46.0 (65.9) | <0.01 | 52.7 (57.5) | 0.6 |
| QST Cold (JND) | 9.1 (3.1) | 9.8 (3.8) | 0.25 | 11.4 (3.8) | 0.06 |
| QST Vibration (JND) | 14.9 (3.0) | 15.5 (2.9) | 0.29 | 19.1 (2.9) | <0.01 |
| Pain and QOL Outcomes | |||||
| Neuro-QOL | 1.8 (0.9) | 2.6 (1.0) | <0.01 | 3.2 (0.9) | <0.01 |
| McGill Pain score | 1.4 (3.8) | 4.4 (5.8) | <0.01 | 12.0 (7.9) | <0.01 |
| VAS Pain score | 7.2 (19.2) | 24 (26.4) | <0.01 | 46.3 (31.6) | <0.01 |
| IDS-SR | 10.4 (8.1) | 17.1 (11.1) | <0.01 | 20.3 (14.1) | 0.28 |
| IWQOL-Lite | 36.2 (8.9) | 82.6 (24.2) | <0.01 | 88.7 (25.1) | 0.29 |
| EuroQol Health state (VAS) | 84.2 (12.9) | 66.3 (20.6) | <0.01 | 54.0 (19.9) | 0.01 |
IENFD=intraepidermal nerve fiber density, PL=peak latency, NR=no response, DML=distal motor latency, CV=conduction velocity, UENS=Utah Early Neuropathy Scale, MNSI=Michigan Neuropathy Screening Instrument, QST=quantitative sensory testing, JND=just normal distance, QOL=quality of life, VAS=visual analog scale, IDS-SR=Inventory of Depressive Symptomatology Self Report, IWQOL-Lite= Impact of Weight on Quality of Life-Lite
*
Measurements for lean controls exclude the lean patient with neuropathy