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In vitro ADME of top four compounds
| Sample ID | Rat liver microsome stability (t1/2, min) | PAMPA Permeability pH 7.4 (1×10–6 cm/s) | PAMPA permeability pH 5 (1×10–6 cm/s) | Solubility (μg/ml) | cLogP |
|---|---|---|---|---|---|
| NCGC00102736 | 1.11 | 1,224.00 | 762.26 | 2.15 | 3.81 |
| NCGC00117671 | 6.39 | Not conclusive | 945.87 | <1 | 4.08 |
| NCGC00117675 | 7.68 | 1,507 | 1,194 | <1 | 3.57 |
| NCGC00117693 | 1.23 | Not conclusive | 590 | 14.7 | 3.94 |
