Table 1.

Eligibility Criteria for ECPR in the Ongoing Clinical Trials.

Inclusion Criteria	Exclusion Criteria
Minnesota Resuscitation Protocol28/ARREST Trial25
VT/VF as first presenting rhythm 18–75 years of age Three EMS-delivered direct current shocks without achieving ROSC Body morphology able to accommodate a Lund University Cardiac Arrest System automated CPR device Estimated transfer time to the scene of the cardiac catheterization laboratory <30 minutes Efficient CPR (end-tidal carbon dioxide <10 mmHg, PaO2 <50 mmHg, lactate <18 mmol/l)	Non-shockable rhythm (asystole or pulseless electrical activity) Cardiac arrest of non-cardiac etiology Contraindications to mechanical CPR Known pregnancy Known prisoners Nursing home residents Valid do not resuscitate/do not intubate orders Known terminal illness Absolute contraindication to angiographic contrast media Active gastrointestinal or internal bleeding
EROCA Trial26
OHCA of presumed non-traumatic etiology requiring CPR Predicted arrival time at ECPR-capable hospital within timeframe specified Witnessed arrest or initial shockable rhythm (VT/VF) Persistent cardiac arrest after initial cardiac rhythm analysis and shock (if shock is indicated)	Sustained ROSC Advanced directive indicating do not resuscitate/do not intubate orders Pre-existing evidence of opting out of study Prisoner Pregnant (obvious or known) ECPR capable emergency department is not at the destination hospital as determined by emergency medical services Legally authorized representative refuses study participation at the scene
INCEPTION Trial24
Age 18–70 years Witnessed OHCA Initial rhythm of VT/VF or AED-shock administered Bystander BLS No ROSC within 15 minutes	ROSC with sustained hemodynamic recovery within 15 minutes Terminal heart failure (New York Heart Association III or IV) Severe pulmonary disease Oncological disease Pregnancy Bilateral femoral vessel bypass surgery Pre-arrest cerebral performance category score of 3 or 4 Mutiple trauma Advanced health care directive Expected initiation of cannulation >60 minutes after arrest
SUB30 Trial27
Witnessed OHCA Presumed cardiac etiology Bystander compression within 3 minutes Remain in cardiac arrest for 20 minutes following the call to emergency services or failure to sustain ROSC in the pre-hospital setting	Known or visible pregnancy No signs of life (physical movement) AND evidence of ineffective chest compressions suggested by: absence of electrical activity at 20 minutes out or end tidal carbon dioxide of less than 1.3 kPa (10 mmHg) Evidence from others present at the scene or patient examination that ECMO unlikely to benefit patient

CPR: Cardiopulmonary resuscitation; OHCA: Out-of-Hospital Cardiac Arrest; ROSC: Return of Spontaneous Circulation; VT/VF: Ventricular Tachycardia/Ventricular Fibrillation.