Table 1.
Population characteristics of 39 chronic kidney disease patients with transiliac bone biopsies from the University of Kentucky
| Age ± SD, y | 64 ± 13 |
|---|---|
| Women, n (%) | 33 (85) |
| Postmenopausal women, n (%) | 6 (18) |
| Black race, n (%) | 1 (3) |
| eGFR ± SD, mL/min/1.73 m2 | 37 ± 14 |
| Diabetes, n (%) | 10 (26) |
| Hypertension, n (%) | 17 (44) |
| CKD stage, n (%) | |
| IIIa | 15 (38) |
| IIIb | 10 (26) |
| IV | 9 (23) |
| V (nondialysis) | 5 (13) |
| Cause of kidney disease, n (%) | |
| Diabetes | 1 (3) |
| Hypertension | 2 (5) |
| Glomerulonephritis | 1 (3) |
| ADPKD | 1 (3) |
| Unspecified | 17 (44) |
| FGF-23 ± SD, pg/mL | 148 ± 132 |
| PTH ± SD, pg/mL | 36 ± 32 |
| α-Klotho ± SD, pg/mL | 713 ± 257 |
| BSAP ± SD, U/L | 26 ± 13 |
| TRAP5b ± SD, U/L | 3.17 ± 1.61 |
| DKK1 ± SD, pmol/L | 36 ± 16 |
| Sclerostin ± SD, pg/mL | 1323 ± 455 |
| Bone histomorphometry | |
| BFR/BS | 0.80 ± 0.91 |
| ACF | 0.27 ± 0.33 |
| OS/BS, % | 11.59 ± 12.18 |
| Ob.S/BS, % | 0.83 ± 1.33 |
| Oc.S/BS, % | 0.76 ± 0.89 |
Abbreviations: ACF, activation frequency; ADPKD, autosomal dominant polycystic kidney disease; BFR/BS, bone formation rate/bone surface; CKD, chronic kidney disease; DKK1, dickkopf-related protein 1; eGFR, estimated glomerular filtration rate; FGF, fibroblast growth factor; Oc.S/BS, osteoclast surface/bone surface; Ob.S/BS, osteoblast surface/bone surface; OS/BS, osteoid surface/bone surface; PTH, parathyroid hormone; TRAP5b, tartrate-resistant acid phosphatase 5b.