Table 3.
Association between bone mineral densitya and incident fractures stratified by low bone turnover vs non–low bone turnover in 641 Health ABC participants with chronic kidney disease
| Incident fractures per SD lower hip BMD | |||||
|---|---|---|---|---|---|
| No. events/No. at risk | Unadjusted | Age-, sex-, race-, and site-adjusted | Fully adjustedb | P interaction | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| Low turnover | 23/103 | 3.26 (2.08-5.11) | 3.97 (2.26-6.97) | 8.10 (3.40-19.30) | .082 |
| Non–low turnover | 111/538 | 1.79 (1.44-2.23) | 1.93 (1.49-2.49) | 2.28 (1.69-3.08) | |
| Incident fractures per SD lower spine BMD | |||||
| No. events/No. at risk | Unadjusted | Age-, sex-, race-, and site-adjusted | Fully adjusted b | P interaction | |
| HR (95% CI) | HR (95% CI) | HR (95% CI) | |||
| Low turnover | 23/103 | 2.90 (1.48-5.71) | 2.90 (1.41-5.94) | 3.53 (1.39-8.96) | .081 |
| Non–low turnover | 111/538 | 1.49 (1.21-1.83) | 1.39 (1.10-1.76) | 1.45 (1.12-1.88) | |
Abbreviations: BMD, bone mineral density; BMI, body mass index; eGFR, estimated glomerular filtration rate; Health ABC, Health Aging and Body Composition Study; HR, hazard ratio; HTN, hypertension; SBP, systolic blood pressure; UACR, urine albumin-to-creatinine ratio.
aPer SD lower BMD, which was 0.16 g/cm2 in the hip and 0.16 g/cm2 in the spine.
bFully adjusted for age, sex, race, site, BMI, SBP, HTN medications, eGFR, UACR, vitD25(OH)2, smoking status, alcohol use, diabetes, physical activity, and diuretics.