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Early molecular model of the levosimendan–cTnC complex: The dihydropyridazinone ring of levosimendan is enclosed within a hydrophobic cleft formed by the amino acid residues Phe20, Ala22, Ala23, Phe24, Val28, and Phe77, and the phenyl ring of levosimendan is aligned to Met81, Cys84, and Met85. Source: Pollesello et al13 Reproduced with permission from the American Society for Biochemistry and Molecular Biology. cTnC = cardiac troponin C.
