Table 3.
The genotype analysis of VDBP polymorphisms.
| Genetic model | Genotype | Controls (n=40) | Patients (n=44) | P value | OR (95% CI) |
|---|---|---|---|---|---|
| VDBP rs7041 | |||||
| P HWE | 0.651 | 0.055 | |||
| Co-dominant model A | TT | 19 (47.5) | 19 (43.2) | 0.145 | Reference |
| TG | 18 (45.0) | 15 (34.1) | 0.83 (0.32–2.12) | ||
| GG | 3 (7.5) | 10 (22.7) | 3.33 (0.79–14.0) | ||
| Dominant model | TT | 19 (47.5) | 19 (43.2) | 0.526 | Reference |
| TG+GG | 21 (52.5) | 25 (56.8) | 1.19 (0.50–2.81) | ||
| Recessive model | TT+TG | 37 (92.5) | 34 (77.3) | 0.053 | Reference |
| GG | 3 (7.5) | 10 (22.7) | 3.62 (0.9–14.2) | ||
| Allelic model | T | 56 (70.0) | 53 (66.3) | 0.185 | Reference |
| G | 24 (300) | 35 (43.7) | 1.53 (0.80–2.94) | ||
| VDBP rs4588 | |||||
| P HWE | 0.563 | 0.117 | |||
| Co-dominant model A | CC | 21 (52.5) | 24 (54.5) | 0.316 | Reference |
| CA | 17 (42.5) | 14 (31.8) | 0.72 (0.28–1.80) | ||
| AA | 2 (5.0) | 6 (13.6) | 2.62 (0.47–14.4) | ||
| Dominant model | CC | 21 (52.5) | 24 (54.5) | 0.851 | Reference |
| CA+AA | 19 (47.5) | 20 (45.5) | 0.92 (0.39–2.17) | ||
| Recessive model | CC+CA | 38 (98.0) | 38 (86.4) | 0.178 | Reference |
| AA | 2 (5.0) | 6 (13.6) | 3.0 (0.56–15.8) | ||
| Allelic model | C | 59 (73.7) | 62 (77.5) | 0.634 | Reference |
| A | 21 (26.3) | 26 (32.5) | 1.17 (0.59–2.33) |
VDBP: vitamin D binding protein. Values are shown as number (%). HWE P; P value of Hardy-Weinberg equilibrium. Chi square (χ2) or Fisher's exact tests were used. OR (95% CI), odds ratio and confidence interval.
(A) represented both heterozygote and homozygote comparison models. Statistically significant results were set at P-value < 0.05.