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. 2020 Jul 7;15(7):e0235702. doi: 10.1371/journal.pone.0235702

Fig 1. Increased pain and paw swelling accompanied by low locomotor activity in the rat CIA model.

Fig 1

Paw withdrawal thresholds (A) were reduced, and paw thickness increased (B) 18 days after collagen-induced arthritis in CIA rats (n = 9) compared to control (n = 9). Both horizontal (C) and vertical (D) activity, which were measured during the dark cycle before testing pain, decreased on the night of day 17 post immunisation in CIA group compared to control. Results represent mean±SEM. *p<0.05, **p<0.01, ***p<0.001, significantly different from control.