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. 2020 Jul 7;15(7):e0235611. doi: 10.1371/journal.pone.0235611

Fig 5. Allele frequency of EGFR L858R mutation of short and long fragment cfDNA in patients with lung cancer.

Fig 5

(A) The protocol to isolate short and long fragments of cfDNA in plasma from patients with lung cancer patients. (B) A representative result of the size distribution obtained with Bioanalyzer. The results of plasma, 10K pellet, 100K pellet, and supernatant are shown. (C-F) Correlation of L858R copy number with the four measures: cfDNA concentration, molarity of short fragment cfDNA, molarity of long fragment cfDNA, and molarity of combined short and long fragment cfDNA. (G) Comparison among sample types of the allele frequency of EGFR L858R mutation by using droplet digital PCR (ddPCR).