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. 2020 Jun 24;16(6):e1008868. doi: 10.1371/journal.pgen.1008868

Fig 3. Accelerated motor symptoms of MitoPark mice by elevated COUP-TFII expression, which can be reversed by L-DOPA treatment.

Fig 3

(A) Open-field assay recorded for Ctrl, OE, MitoPark, and MitoPark/OE mice at 5–6, 9–10, and 13–14 weeks of age. n = 5-8/group. (B) Rotarod performance test recorded for 15- to 18-week-old mice. n = 7/group. (C) Pole test recorded for 12- to 15-week-old mice. n = 7-8/group. (D) Open-field assay recorded for 15- to 16-week-old mice treated with L-DOPA (20 mg/kg). The arrows indicate reagent addition steps. Before, averaged activity from 0 to 30 minutes (pre-L-DOPA treatment); After, averaged activity from 75 to 105 minutes (post-L-DOPA treatment). n = 7-9/group. (A-D) *p < 0.05; **p < 0.01; ***p < 0.001. Mean ± SEM. One-way ANOVA Fisher’s LSD post hoc test. See also S3 Fig.