Skip to main content
. Author manuscript; available in PMC: 2020 Jul 7.
Published in final edited form as: Sci Signal. 2019 Jul 23;12(591):eaao0736. doi: 10.1126/scisignal.aao0736

Fig. 7. The balance between distinct p38 pathways tunes pro- and anti-inflammatory T cell responses.

Fig. 7.

(A) Selective disruption of the alternative p38 pathway by Y323F substitution in P38α and P38β (P38αβY323F) impairs proinflammatory TH1 and TH17 cell IFN-γ and IL-17 production (35, 36). (B) Uncoupling of the classical p38 pathway by SOS1/2 deletion reduces iTreg cell differentiation, which counteracts the proinflammatory T cell functions of p38 activation. (C) The functional dichotomy between pro- and anti-inflammatory T cell responses is determined by the cooperation of two distinct p38 activation pathways.