Skip to main content
. 2019 Jul 10;41(26):2487–2497. doi: 10.1093/eurheartj/ehz459

Figure 1.

Figure 1

Overexpression of LAV-BPIFB4 improves the vascular reactivity of ApoE null mice fed, a high-fat diet, and a CXCR4 inhibitor abolishes this protective effect. (A) Experimental protocol; (B) vascular response of ex vivo mesenteric arteries from ApoE knockout mice to potassium (80 mmol/L KCl) and (C) the dose–responses to phenylephrine, (D) acetylcholine, and (E) nitroglycerine after 1 month of AAV-LAV-BPIFB4 treatment. AAV-GFP was used as a control. Values are mean ± standard deviation of eight independent experiments. B, C, D, E two-way ANOVA followed Tukey’s multiple comparisons test. Numbers next to the curve show adjusted P-values. (F) Representative western blot (left) and densitometric analysis (right) conducted on mesenteric artery lysates. Values are mean ± standard deviation (N = 3). One-way ANOVA followed Tukey’s multiple comparisons test. Numbers above square brackets show adjusted P-values.