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. 2020 May 30;4(7):e10367. doi: 10.1002/jbm4.10367

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© 2020 The Authors. JBMR Plus published by Wiley Periodicals, Inc. on behalf of American Society for Bone and Mineral Research.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Effects of 11‐day treatment (12‐day study) with M‐PTH/PTHrP or alfacalcidol on serum calcium (sCa) in thyroparathyroidectomized (TPTX) rats. TPTX rats were treated for 11 days with daily s.c. injection of either vehicle or M‐PTH/PTHrP, or with daily oral alfacalcidol at the indicated doses, and sham‐surgery control rats were s.c. injected daily with vehicle. The levels of Ca in serum and urine were assessed. Blood samples were collected from the jugular vein at 8 hours (A) and at 24 hours (B) after the last treatment administration, and assessed for total sCa. Total urine was collected in metabolic cages over the time intervals of 0 to 8 hours (C), and 8 to 24 hours (D) and assessed for total urinary Ca. Data are means ± SEM; n = 6 or 5 (2.0 and 4.0 nmol/kg of M‐PTH/PTHrP); *p < 0.05 M‐PTH/PTHrP versus TPTX‐vehicle; #p < 0.05 TPTX vehicle versus sham.