Table 1.

Effects of rHuEPO on markers in rest

Parameter	Treatment	Raw baseline	EM Day 11	EM Day 14	EM Day 25	EM Day 28	EM Day 39	EM Day 42	EM Day 53	EM Pre-race	Difference between groups
E-selectin, pg/mL	Placebo	5100 (1978)	4986	4964	5097	5166	4731	4740	4942	4953	8.6% (2.0%, 15.7%) p = 0.011
	rHuEPO	5543 (1912)	5446	5117	5475	5270	5568	5251	5477	5387
P-selectin, pg/mL	Placebo	8789 (2112)	9037	8714	8524	8930	8810	8721	8261	8599	7.8% (1.5%, 14.5%) p = 0.016
	rHuEPO	9710 (2285)	9010	9120	9248	9590	9846	9267	9173	9789
iCAM, pg/mL	Placebo	318333 (48913)	320475	313774	321983	326577	317702	297252	306471	320147	2.2% (− 2.2%, 6.8%) p = 0.33
	rHuEPO	335958 (73686)	322643	322951	328572	330397	330440	310291	311309	322155
vCAM, pg/mL	Placebo	489750 (84683)	527396	482540	506971	502660	498766	493731	514184	493716	− 0.0% (− 4.2%, 4.4%) p = 0.99
	rHuEPO	515000 (102348)	520718	480747	485750	496181	504203	508575	507573	515472
Von Willebrand Factor, %	Placebo	88.4 (27.7)	81.953	86.168	85.932	91.320	86.046	88.634	83.627	90.113	− 0.9 (− 8.0%,6.8%) p = 0.8138
	rHuEPO	100.1 (25.4)	87.897	86.114	82.513	94.138	80.810	86.512	81.131	89.014
PF4, pg/mL	Placebo	43019 (46073)	68339	23340	51235	28821	33209	35929	33026	63845	13.1% (− 9.3%, 41.1%) p = 0.2661
	rHuEPO	43988 (85138)	60195	23125	60555	31296	52786	36164	43549	72593

Raw baseline (and SD) and EM (Estimated Mean) values of coagulation and endothelial activation markers in rest at the different time points for both treatment groups, including the estimated differences between the treatment groups (95% confidence interval) and p value. Data analyzed with a mixed model analysis of variance with fixed factors treatment, time and treatment by time, random factor participant and the pre-value as covariate