Table 1.

Biographical information of the study cohort. Number of cases, CERAD score, NIA-AA classification (none, low, intermediate (Inter) and high degree of AD-related neuropathological change), sex (% male), age at death, post-mortem interval (PMI) and cortical pH are indicated, stratified according to diagnosis, neuropathological severity and individual Braak stage. Mean values presented alongside ± SEM

	No. cases	CERAD	NIAA	Male (%)	Age range (years)	Mean age (years)	PMI range (h)	Mean PMI (h)	pH range	Mean pH
Diagnosis (Braak stage)
Non-AD (0–3)	27	C0-C2	None–Inter	44.4	74–103	86 ± 1.4	11–110	44.9 ± 5.2	5.4–6.9	6.3 ± 0.1
AD (4–6)	19	C2-C3	Inter–High	60	71–90	83.4 ± 1.2	20–87	46.6 ± 4.9	6–6.9	6.3 ± 0.1
Severity (Braak stage)
Low (0–2)	18	C0-C1	None–Low	66.7	74–103	85.3 ± 1.9	11–92	40.7 ± 6.2	6–6.7	6.3 ± 0.1
Moderate (3–4)	14	C0-C3	None–Inter	28.6	77–95	85.9 ± 1.5	13.5–101	51.5 ± 7	5.4–6.9	6.2 ± 0.2
Severe (5–6)	14	C1-C3	Inter–High	71.4	71–90	83.6 ± 1.5	20–78	46 ± 5.7	6.1–6.9	6.4 ± 0.1
Braak stage
0	3	C0	None	100	74–78	76.7 ± 1.3	11–56	30 ± 13.5	6–6.1	6.1 ± 0.1
2	15	C0-C1	None–Low	40	74–103	87 ± 2	12–92	42.8 ± 7	6–6.7	6.3 ± 0.1
3	9	C0-C2	None–Inter	33.3	78–95	87.6 ± 1.7	13.5–101	53.4 ± 9.5	5.4–6.9	6.2 ± 0.3
4	5	C2-C3	Inter	40	77–88	82.8 ± 2.2	26–87	48.2 ± 10.6	6.0–6.8	6.2 ± 0.2
5	6	C1-C3	Inter–High	83.3	82–88	83.8 ± 1.2	22–78	50.5 ± 10.1	6.1–6.6	6.3 ± 0.1
6	8	C3	Inter—High	50	71–90	83.5 ± 2.4	20–69	42.6 ± 6.9	6.3–6.9	6.5 ± 0.1