Table 2.

Skin permeation parameters measured for finasteride in different dermatological formulations. Cumulative amount permeated (Q₂₄), flux between 18 and 24 h ( J_{18 − 24}), lag time (T_L), pathlength normalized partition coefficient (Kh), pathlength normalized diffusion coefficient (D/h²) were measured for both physiological skin temperature (32°C) and elevated skin temperature (45°C) using Fick’s first law (Mean ± SEM, n = 6)

Vehicle	Membrane temperature (°C)	J18 − 24 (μg/cm2/h)	ER	Q24 (μg/cm2)	ER	TL (hr)	D/h2(×10−2 h−1)	ER	Kh (cm)	ER
DPA	32	1.089 ± 0.01	2.16	19.48 ± 1.97	2.20	6.99 ± 0.38	2.38 ± 0.44	1.00	45.67 ± 2.48	2.16
	45	2.352 ± 0.13*		43.30 ± 3.00*		7.00 ± 0.37	2.38 ± 0.45		98.78 ± 5.22*
DMI	32	1.098 ± 0.06	2.90	17.82 ± 1.36	3.50	6.60 ± 0.45	2.52 ± 0.37	1.46	43.48 ± 2.96	1.98
	45	3.184 ± 0.26*		62.43 ± 4.25*		4.52 ± 0.60*	3.69 ± 0.28*		86.35 ± 11.46*
IPA	32	3.555 ± 0.28	5.67	62.75 ± 7.04	5.46	6.31 ± 0.49	2.64 ± 0.34	1.02	177.68 ± 10.45	5.56
	45	20.138 ± 1.57*		342.62 ± 27.84*		6.18 ± 0.30	2.70 ± 0.56		746.72 ± 36.25*
PG	32	4.626 ± 0.41	3.61	80.58 ± 7.30	3.82	6.63 ± 0.56	2.51 ± 0.30	1.06	184.02 ± 15.54	3.42
	45	16.696 ± 1.50*		307.42 ± 37.61*		6.29 ± 0.30	2.65 ± 0.56		630.11 ± 30.54*
TP	32	1.656 ± 0.11	3.04	26.46 ± 2.15	3.66	7.25 ± 0.49	2.30 ± 0.34	1.73	72.04 ± 4.87	1.75
	45	5.028 ± 0.74*		96.77 ± 10.44*		4.20 ± 0.53*	3.97 ± 0.31*		126.71 ± 15.99*

*denotes significant difference in the parameter at 45°C for each vehicle compared to the same respective vehicle at 32°C