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. 2020 Jul 3;43(6):593–629. doi: 10.1007/s12272-020-01247-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Mechanism of neuropharmacological activity of mistletoe, GABAergic signalling. Mistletoe compounds might be positive allosteric modulators of GABA_A receptor. They might bind to benzodiazepine site increasing the binding affinity of the receptor for GABA. This results in increased frequency of chloride ion channel opening, increased influx of chloride ions and hyperpolarization leading to anticonvulsant, sedative and anxiolytic activity