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. 2020 Jul 3;43(6):593–629. doi: 10.1007/s12272-020-01247-w

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Probable effect of mistletoe on muscle mitochondrial activity. Two major genes related to mitochondrial biogenesis and function are SIRT-1 and PGC-1α. PGC-1α translocates into the nucleus where it is phosphorylated by AMPK and deacetylated by SIRT-1. Once phosphorylated and deacetylated, PGC-1α activity is increased, leading to increased transcription of mitochondrial genes. Korean mistletoe increases the mRNA expression of PGC-1α and SIRT-1 and increases the expression of PGC-1α transcriptional targets such as PGC-1β, NRF-1, ERRα, Tfam, PPARβ/δ, myoglobin and TNNI2