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. 2020 Mar 28;36(7):685–695. doi: 10.1007/s12264-020-00486-7

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Attenuated pinprick-evoked responses in conditional Nfia null mice. A General motor coordination, assessed by the accelerating rotarod test, in Nfia^F/F;Wnt1-Cre and Nfia^F/F control mice (n = 8/group, Student’s unpaired t-test, P = 0.8812, t₍₁₄₎ = 0.1521). B Normal reflex responses to light touch in the dynamic brush assay in Nfia^F/F control (n = 10) and Nfia^F/F;Wnt1-Cre CKO mice (n = 9) (Student’s unpaired t-test, P = 0.478, t₍₁₇₎ = 0.7255). C Normal reflex responses to radiant heat in the Hargreaves assay (n = 7/group, Student’s unpaired t-test, P = 0.318, t₍₁₂₎ = 1.042). D Normal reflex responses to noxious cold in the dry ice assay (n = 8/group, Student’s unpaired t-test, P = 0.5403, t₍₁₄₎ = 0.6277). E Withdrawal thresholds in response to von Frey filament stimulation in Nfia^F/F;Wnt1-Cre CKO (n = 8) and Nfia^F/F control mice (n = 7) (Student’s unpaired t-test, P = 0.0045, t₍₁₃₎ = 3.425). F Pinprick scores evoked by a sharp steel pin glued to the tip of a 1.0-g von Frey filament in Nfia^F/F;Wnt1-Cre (n = 6) and Nfia^F/F control mice (n = 7) (Student’s unpaired t-test, P < 0.0001, t₍₁₁₎ = 14.63). G Noxious pinch-evoked licking responses in Nfia^F/F control and Nfia^F/F;Wnt1-Cre mice (n = 7/group, Student’s unpaired t-test, P = 0.3472, t₍₁₂₎ = 0.9783).