Table 1.
Characteristics of the study participants.
| Characteristics | sAD (n = 462) | Control (n = 463) | P value |
|---|---|---|---|
| Age, mean (SD), years | 69.75 (9.84) | 68.85 (10.12) | 0.17 |
| Female, n (%) | 243 (52.6) | 193 (41.7) | 0.001 |
| MMSE score, mean (SD) | 14.41 (7.55) | 24.84 (3.97) | <0.001 |
| APOE ε4 carriers, n (%) | 191 (41.3) | 101 (21.8) | <0.001 |
| CSF Aβ42, pg/mL, mean (SD) | 632.60 (233.16) | 1265.39 (437.02) | <0.001 |
| CSF Aβ40, pg/mL, mean (SD) | 8519.27 (3846.22) | 11276.15 (4502.05) | <0.001 |
| CSF Aβ42/Aβ40, mean (SD) | 0.092 (0.092) | 0.13 (0.088) | <0.001 |
| CSF T-tau, pg/mL, mean (SD) | 527.62 (443.62) | 219.74 (112.09) | <0.001 |
| CSF P-tau, pg/mL, mean (SD) | 70.03 (39.19) | 47.82 (16.72) | <0.001 |
Differences between groups were assessed using Mann–Whitney U tests (for numerical variables) or χ2 tests (for categorical variables); sAD, sporadic Alzheimer’s disease; MMSE Mini-Mental State Examination; APOE, apolipoprotein E; CSF, cerebrospinal fluid.