Table 2.

Allele distribution of the significant SNPs.

SNP	Neighboring Gene	Risk allele	Risk allele frequency		OR (95% CI)	P value
			sAD	Control
rs429358	APOE	C	0.25	0.12	2.55 (1.99–3.28)	<0.001
rs7412	APOE	T	0.05	0.07	0.62 (0.42–0.92)	0.02
rs6733839	BIN1	T	0.45	0.38	1.30 (1.08–1.57)	0.007
rs7561528	BIN1	A	0.13	0.10	1.38 (1.03–1.85)	0.032
rs3865444	CD33	A	0.17	0.22	0.72 (0.57–0.91)	0.006
rs3826656	CD33	A	0.30	0.34	0.81 (0.66–0.98)	0.03
rs11771145	EPHA1	G	0.48	0.43	1.25 (1.04–1.50)	0.02
rs561655	PICALM	G	0.43	0.49	0.78 (0.65–0.94)	0.01
rs541458	PICALM	T	0.47	0.53	0.79 (0.65–0.95)	0.01
rs10792832	PICALM	A	0.35	0.40	0.81 (0.67–0.98)	0.03
rs3851179	PICALM	T	0.35	0.39	0.81 (0.67–0.99)	0.04
rs11218343	SORL1	C	0.26	0.31	0.78 (0.64–0.96)	0.02
rs3781834	SORL1	G	0.19	0.23	0.79 (0.63–0.99)	0.04
rs2075650	TOMM40	G	0.23	0.11	2.32 (1.79–3.00)	<0.001

The ORs and 95% CIs were adjusted for age, sex, and APOE ε4 status; SNP, single-nucleotide polymorphism; OR, odds ratio; CI, confidence interval.