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. 2020 Apr 18;36(7):778–792. doi: 10.1007/s12264-020-00493-8

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© The Author(s) 2020

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Fig. 3 — Sequence analysis of gSOCS3. A–C Sequence alignment of SOCS3 proteins of vertebrates. Gaps introduced into sequences to optimize alignment are represented by dashes. The kinase inhibitory region (KIR) domain (A), a central Src-homology 2 (SH2) domain (B), and a C-terminal SOCS box (C). The 12-amino-acid extended SH2 subdomain (ESS) is underlined. D Unrooted phylogenetic tree of SOCS3 proteins from the representative species constructed by the neighbor-joining method in the PHYLIP 3.5c package. Bootstrap majority consensus values on 1000 replicates are indicated at each branch point as percentages. The sequences from GenBank are gecko Gekko japonicus SOCS3 (XP_015272482); human Homo sapiens SOCS3 (NP_003946); mouse Mus musculus SOCS3 (NP_031733); chicken Gallus gallus SOCS3 (NP_989931); green anole Anolis carolinensis SOCS3 (XP_008102404); frog Xenopus tropicalis SOCS3 (NP_001005696); and zebrafish Danio rerio SOCS3 (NP_998469).