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. 2020 Apr 18;36(7):778–792. doi: 10.1007/s12264-020-00493-8

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© The Author(s) 2020

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Fig. 5 — gSOCS3 negatively regulates the phosphorylation of STAT1/3/5 through the KIR domain. A–D Macrophages were transfected with GV314-SOCS3 or GV314-mSOCS3 (F4A in KIR domain) adenovirus for 48 h before treatment with 0.1 mol/L PBS (pH 7.4) (A), 10 ng/mL IFN-γ (B), 50 ng/mL GM-CSF (C), or combinations of 50 ng/mL GM-CSF and 10 ng/mL IFN-γ (D) for 2 h. Phosphorylation of STAT1/3/5 was determined by Western blot. Data are expressed as the mean ± SEM; *P < 0.05.