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. 2020 Apr 18;36(7):778–792. doi: 10.1007/s12264-020-00493-8

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© The Author(s) 2020

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Fig. 6 — gSOCS3 binds with JAK1 and JAK2 to negatively regulate the activation of STAT1/3/5. A Binding assays of gSOCS3 with JAK1/2 in macrophages transfected with GV314-SOCS3 adenovirus for 72 h. Immunoprecipitation using anti-Flag antibody and detection of the components of the Flag(SOCS3)-associated complexes with anti-JAK1 or -JAK2 antibody. B, C Addition of 100 μmol/L JAK1/2 inhibitor AG490 decreases the levels of pSTAT1/3/5 in the context of stimulation with the cytokine GM-CSF or IFN-γ.