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. 2020 Jul 7;10:11191. doi: 10.1038/s41598-020-68168-y

Table 2.

Summary of toxicities among patients with thymic epithelial tumors after radiotherapy.

No Age Sex Event Time to event (months) Details MLD (Gy) Lung V20 (%) MHD (Gy) PA V35 (Gy)
1 58 F G2 RP 9 Symptomatic; medication required 12.3 21.8 8.5 75.4
2 59 F G2 RP 2 Symptomatic; medication required 13.9 20.8 18.4 99.6
3 44 F G2 RP 9 Symptomatic; medication required 11.8 21.6 29.4 94.1
4 55 F G2 RP 5 Symptomatic; medication required 8.3 11.4 10.3 69.5
5 50 F G2 RP 3 Symptomatic; medication required 16.7 35.3 44.9 100
6 72 M G2 RP 5 Symptomatic; medication required 11.4 22.8 5.0 32.3
7 63 M G2 RP 2 Symptomatic; medication required 5.5 9.6 14.2 94.7
8 59 F G2 RP 2 Symptomatic; medication required 17.2 37.0 33.6 100
G3 Carditis 18 Constrictive pericarditis; pericardiotomy required
9 57 F G2 RP 2 Symptomatic; medication required 16.3 36.6 39.8 100
G5 Carditis 40 Heart failure due to constrictive pericarditis
10 66 M G3 RP 1 Hospitalization required 8.5 12.9 9.3 53.5
11 70 F G3 RP 6 Hospitalization required 12.1 26.1 18.2 85.4
12 82 M G3 RP 2 Hospitalization required 16.3 27.7 34.3 89.9
G3 Carditis 8 Constrictive pericarditis and effusion; conservatively managed
13 76 M G5 RP 2 Respiratory failure due to refractory RP 17.0 33.7 14.6 100
14 56 F G3 Carditis 9 Constrictive pericarditis; pericardiotomy required 15.3 33.0 40.7 100

Data were described as equivalent 2-Gy fractions (EQD2) using the LQ model with α/β = 3 Gy.

MLD mean lung dose, V20 percentage volume receiving at least 20 Gy, MHD mean heart dose, G grade, RP radiation pneumonitis, PA pulmonary artery, V35 percentage volume receiving at least 35 Gy.