Table 1. The prognostic value of immune checkpoint genes in breast cancer.
Gene | Affymetrix IDs | OS | RFS | ||||
---|---|---|---|---|---|---|---|
HR | 95% CI | P-value | HR | 95% CI | P-value | ||
ADORA2A | 205013_s_at | 0.91 | 0.74–1.13 | 0.4 | 0.83 | 0.75–0.93 | 0.00093 |
LAG-3 | 206486_at | 0.94 | 0.76–1.17 | 0.59 | 0.88 | 0.79–0.99 | 0.026 |
TIM-3 | 235458_at | 1.07 | 0.78–1.46 | 0.67 | 1.09 | 0.93–1.27 | 0.3 |
PD1 | 207634_at | 0.84 | 0.68–1.04 | 0.11 | 0.74 | 0.67–0.83 | 8.5E-08 |
CTLA-4 | 236341_at | 0.55 | 0.4–0.76 | 0.00023 | 0.67 | 0.57–0.78 | 4.2E-07 |
IDO1 | 210029_at | 0.84 | 0.68–1.04 | 0.11 | 0.89 | 0.8–0.99 | 0.034 |
B7-H3 | 224859_at | 1.38 | 1–1.9 | 0.048 | 1.18 | 1.01–1.38 | 0.035 |
TIGIT | 240070_at | 0.67 | 0.49–0.92 | 0.012 | 0.77 | 0.66–0.9 | 0.0011 |
CD80 | 1554519_at | 0.84 | 0.61–1.14 | 0.26 | 0.9 | 0.77–1.05 | 0.19 |
CD86 | 205685_at | 0.97 | 0.78–1.2 | 0.78 | 0.93 | 0.83–1.04 | 0.19 |
CD28 | 206545_at | 0.82 | 0.66–1.02 | 0.08 | 0.71 | 0.64–0.79 | 1.1E-09 |
CD160 | 207840_at | 0.88 | 0.71–1.09 | 0.26 | 0.75 | 0.67–0.84 | 2.80E-07 |
LIGHT | 207907_at | 0.94 | 0.76–1.17 | 0.6 | 0.84 | 0.76–0.94 | 0.0024 |
CD40 | 215346_at | 0.81 | 0.65–1 | 0.05 | 0.81 | 0.73–0.9 | 0.00017 |
CD40LG | 207892_at | 0.83 | 0.67–1.03 | 0.096 | 0.8 | 0.71–0.89 | 3.90E-05 |
CD200 | 209583_s_at | 0.85 | 0.69–1.06 | 0.15 | 0.82 | 0.73–0.91 | 0.00034 |