Table 2.
miRNAs role in cancer. The table shows miRNAs modulated by Resveratrol (Table 2A for up-regulated and Table 2B for down-regulated, respectively); their epigenetic mechanism in cancer is indicated along the bibliographic references. For full references refer to Supplementary file 1 Reference List.
| A. Up-regulated miRNAs. | ||||
|---|---|---|---|---|
| miRNA | Mechanism | Gene Target | Cancer | Reference |
| miR-1207-5p |
Inhibits tumor growth, invasion and metastasis. | hTERT | Gastric | [64] |
| Inhibits EMT induced by TGF-β and EGF, by indirectly down-regulating PI3K/AKT pathway, STAT3 and some important inflammatory mediators. | CSF1 | Lung | [65] | |
| Suppresses invasion and metastasis by targeting genes related to cell migration. | CD151 | Nasopharyngeal | [66] | |
| Prevents tumor growth and invasion through the inhibition of AKT/mTOR signaling pathway. | FASN | Hepatocellular | [67] | |
| Increases sensitivity to gemcitabine and reduces cancer growth. | SRC | Pancreatic | [68] | |
| miR-1225-5p |
Lower expressed in stage III and IV compared to I and II; suppresses cell migration and invasion. | IRS1 | Glioblastoma | [69] |
| Prevents tumor cell proliferation and metastasis by inhibiting the activation of Wnt/β-catenin pathway. | SIRT3 | Thyroid | [70] | |
| Acts as tumor suppressor by preventing tumor growth, metastasis and invasion through down-regulation of β-catenin. | IRS1 | Gastric | [71] | |
| miR-1915-3p | Reduces cell migration and proliferation. | SETD1A | Breast | [72] |
| Inhibits tumor progression and promotes apoptosis. | BCL-2 | Gastric | [73] | |
| B. Down-regulated miRNAs. | ||||
|---|---|---|---|---|
| miRNA | Mechanism | Gene Target | Cancer | Reference |
| miR-494 | Oncogenic miRNA associated with poor prognosis and metastasis, promotes invasion and cell migration. | PTEN | Colorectal | [74] |
| Associated with short overall survival; its expression is negatively correlated with tumor grade; high expression promotes early invasion and metastasis. | PTEN | Lung cancer | [75] | |
| Promotes proliferation, migration and invasion through the activation of PI3K/AKT pathway. (-3p) | PTEN | Endometrial | [76] | |
| Enhances proliferation, invasion and metastasis. (-3p) | SOX7 | Nasopharyngeal | [77] | |
| Inhibits apoptosis and promotes cell growth and invasiveness through PTEN/AKT signaling. (-3p) | PTEN | Glioblastoma | [78] | |
| Stimulates tumor progression and proliferation by activating Wnt/β-catenin pathway. | APC | Colorectal | [79] | |
| Promotes tumorigenesis through the inhibition of apoptosis inducted by cisplatin. | CASP2 | Lung | [80] | |
| Associated to poor prognosis and bad clinical outcome, promotes carcinogenesis, tumor growth and proliferation by up-regulating PI3K/AKT pathway. | PTEN | Cervical | [81] | |
| Contributes to cell cycle progression, cell viability, invasion and migration via activation of PI3K/AKT pathway. | PTEN | Hepatocellular | [82] | |