Table 2.
Transfusion Scenario 1: Non-LR, WB transfusion between recipient and donor who are homozygous at multiple loci.
| HLA Locus | Recipient A Type WBC: 10.0 × 103/μl | Donor A HLA Type WBC: 4.3 × 103/μl | No. of distinct antigens/alleles detected at locus | Recipient and donor antigens/alleles detected in 10 unit transfusion scenario | Recipient and donor antigens/alleles detected in 2 unit transfusion scenario | Recipient and donor antigens/alleles detected in 1 unit transfusion scenario | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| R* | D** | R | D | R | D | ||||||
| A | *01 | *03 | *23 | *30 | 4 | *01, *03 | *23, *30 | *01, *03 | *23, *30 | *01, *03 | *23 |
| B | *08 | XX | *07 | *44 | 3 | *08 | *07, *44 | *08 | *07, *44 | *08 | *07 |
| C | *07 | XX | *04 | *15 | 3 | *07 | *04, *15 | *07 | *15 | *07 | *15 |
| DRB1 | *03:01(17) | XX | *11 | XX | 2 | *03:01 | *11 | *03:01 | *11 | *03:01 | *11 |
| DRB3/4/5 | DRB3*01 | XX | DRB3 *02 | XX | 2 | DRB3*01 | DRB3*02 | DRB3*01 | DRB3*02 | DRB3*01 | None |
| DQA1 | *05:01 | XX | *01 | XX | 2 | *05:01 | *01 | *05:01 | *01 | *05:01 | *01 |
| DQB1 | *02 | XX | *06:02 | *06:03 | 3 | *02 | *06:02, *06:03 | *02 | *06:02 | *02 | *06:02 |
| DPA1 | *01 | *02:01 | *01 | *03 | 3 | *02:01, *01 (I***) | *03, *01 (I) | *02:01, *01 (I) | *03, *01 (I) | *02:01, *01 (I) | *03, *01 (I) |
| DPB1 | *04:02 | *09:01 | *03:01 | *40:01 | 4 | *04:02, *09:01 | *03:01, *40:01 | *04:02, *09:01 | *03:01, *40:01 | *04:02, *09:01 | *40:01 |
R = recipient allele detected based on positive recipient-specific wells.
D = donor allele detected based on positive donor-specific wells.
I = indeterminant; DNA source could not be determined due to recipient and donor sharing antigen/allele at that locus.