Fig. 3.

Somatically altered pathways in OCCC patients. (a) Somatically altered genes in the PI3K/AKT, (b) TP53, (c) ERBB2 and (d) chromatin remolding pathways. Non-synonymous somatic mutations and copy number deletions were considered as inactivating mutations (shades of blue), while copy number amplifications were considered as activating mutations (shades of red). (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)