Table 3.

MSigDB canonical pathway database enrichment for recurrent mutant genes in OCCC samples. This table presents the top 20 modules. Module: name of the module.

Gene Set Name	Genes in Gene Set (K)	Description	Genes in Overlap (k)	k/K	p-value	FDR q-value
KEGG_PATHWAYS_IN_CANCER	328	Pathways in cancer	25	0.0762	5.43E−18	7.22E−15
PID_P53_DOWNSTREAM_PATHWAY	137	Direct p53 effectors	13	0.0949	3.58E−11	2.18E−08
KEGG_TYPE_II_DIABETES_MELLITUS	47	Type II diabetes mellitus	9	0.1915	6.19E−11	2.18E−08
KEGG_PROSTATE_CANCER	89	Prostate cancer	11	0.1236	6.55E−11	2.18E−08
REACTOME_DEVELOPMENTAL_BIOLOGY	396	Genes involved in Developmental Biology	19	0.048	1.82E−10	4.84E−08
REACTOME_SIGNALLING_BY_NGF	217	Genes involved in Signalling by NGF	14	0.0645	1.08E−09	2.39E−07
KEGG_THYROID_CANCER	29	Thyroid cancer	7	0.2414	1.52E−09	2.84E−07
SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES	67	Genes related to PIP3 signaling in cardiac myocytes	9	0.1343	1.71E−09	2.84E−07
KEGG_FOCAL_ADHESION	201	Focal adhesion	13	0.0647	4.15E−09	6.13E−07
REACTOME_IMMUNE_SYSTEM	933	Genes involved in Immune System	26	0.0279	9.84E−09	1.31E−06
KEGG_COLORECTAL_CANCER	62	Colorectal cancer	8	0.129	1.93E−08	2.33E−06
REACTOME_ADAPTIVE_IMMUNE_SYSTEM	539	Genes involved in Adaptive Immune System	19	0.0353	2.77E−08	3.07E−06
KEGG_NOTCH_SIGNALING_PATHWAY	47	Notch signaling pathway	7	0.1489	5.45E−08	5.58E−06
PID_HES_HEY_PATHWAY	48	Notch−mediated HES/HEY network	7	0.1458	6.34E−08	6.02E−06
SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES	51	Genes related to the insulin receptor pathway	7	0.1373	9.79E−08	8.67E−06
KEGG_ENDOMETRIAL_CANCER	52	Endometrial cancer	7	0.1346	1.12E−07	9.34E−06
REACTOME_SIGNALING_BY_FGFR	112	Genes involved in Signaling by FGFR	9	0.0804	1.64E−07	1.12E−05
PID_FGF_PATHWAY	55	FGF signaling pathway	7	0.1273	1.67E−07	1.12E−05
BIOCARTA_ERK5_PATHWAY	18	Role of Erk5 in Neuronal Survival	5	0.2778	1.68E−07	1.12E−05
BIOCARTA_PTEN_PATHWAY	18	PTEN dependent cell cycle arrest and apoptosis	5	0.2778	1.68E−07	1.12E−05