Figure 6.

Radioimmunotherapy (RIT) of orthotopic anaplastic thyroid cancers (ATCs). A) Kaplan–Meier survival curves. A significant difference in median survival was observed between mice treated with ¹³¹I‐ALT‐836 and normal saline (control group) (p = 0.0089), or ¹³¹I‐IgG (p = 0.0016). When compared to the control group, no significant survival improvement was observed for mice receiving ALT‐836 (p = 0.7773) or free ¹³¹I treatment (p = 0.8056). B) Macroscopic H&E staining of an orthotopic tumor from the ¹³¹I‐ALT‐836 treatment group. The tumor (black dashed circle) did not compress the adjacent trachea. C) The tumor tissue is devoid of any thyroid follicles. D–F) Macroscopic H&E staining of archived tumor tissue in the control group showed irregular bilateral tumors (black dashed circles), effaced and infiltrated thyroid follicles (blue arrows), and invaded muscle (dark green arrow and dashed circle).