| Amsacrine |
Topoisomerase inhibitors |
DNA intercalation and inhibition of topoisomerase II, causing DNA double-strand breaks, cell cycle arrest, and cell death |
| Bleomycin |
Antitumor antibiotic |
Forms complexes with iron that reduce molecular oxygen to form free radicals which in turn cause DNA single- and double-strand breaks |
| Bortezomib |
Proteosome inhibitors |
Reversibly inhibits the 26S proteosome and inhibits nuclear factor (NF)-kappaB causing disruption of various cell signaling pathways, cell cycle arrest, and cell death. |
| Carmustine |
Alkylating agents |
Alkylates and cross-links DNA causing cell cycle arrest and cell death |
| Cisplatin |
Alkylating agents |
Alkylates and cross-links DNA causing cell cycle arrest and cell death |
| Etoposide |
Topoisomerase inhibitors |
Binds to and inhibits topoisomerase II causing an increase of DNA single- and double-strand breaks, cell cycle arrest, and cell death |
| Puromycin |
Aminonucleoside antibiotic |
Acts as analog of 3′ terminal end of aminoacyl-tRNA and incorporates itself into growing polypeptide chain causing premature termination and inhibition of protein synthesis |
| Silver |
NA |
Multi-faceted induction of apoptosis |
