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. 2020 May 28;9(2):CNS58. doi: 10.2217/cns-2020-0004

Table 2. . Repurpose suggestion of drug and basic substance characteristics.

  Molecular properties Clinical properties Ref.
  Molecular 3D stucture Molecular formula Molecular weight Mechanism of action Brands/other names Indications Adult dosing  
Trihexyphenidyl graphic file with name cns-09-58-T2a.gif C20H31NO 301.5 g/mol Muscarinic receptor-ACh antagonist Artane, Trihex Parkinsonism and extrapyramidal symptoms Up to 15 mg/day, oral administration [11]
Homatropine graphic file with name cns-09-58-T2b.gif C16H21NO3 275.34 g/mol Anticholinergic Isopto Homatropine Mydriasis, uveitis Up to 5 daily drops from 2% ocular solution [11]
Rizatriptan graphic file with name cns-09-58-T2c.gif C15H19N5 269.34 g/mol 5-HT agonist Maxalt Migraine headache Up to 30 mg/day, oral administration [11]

ACh: Acetylcholine; 5-HT: Serotonin.