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. 2020 Apr 6;116(9):1557–1570. doi: 10.1093/cvr/cvaa082

Figure 1.

Figure 1

The cardiac voltage-gated sodium channel NaV1.5. Upper panel: unfolded NaV1.5 protein at the cardiomyocyte plasma membrane featuring four domains (I, II, III, IV) each containing six segments (S1–S6). The charged segment S4 is represented in green. Lower left panel: folded NaV1.5 at the cardiomyocyte plasma membrane. The rapid inward sodium current depolarizes the cell membrane. Lower right panel: relation between the sodium current and the upstroke of the action potential (green segments).