Figure 5.

Thrifty subjects have a higher 24EE at any level of fat-free mass than spendthrift subjects Relationships between fat-free mass and 24EE during (A) 24h energy balance and during (B) 24h fasting, separated by metabolic groups. Thrifty subjects are denoted in red, spendthrift subjects are denoted in green. In a linear regression analysis including the phenotypic group (thrifty vs spendthrift) and fat-free mass as determinants, thrifty subjects had higher 24EE than spendthrift subjects at any level of fat-free mass during energy balance (+101 kcal/day, 95% CI, +29, +173; P = 0.006) but not during fasting conditions (P = 0.67). Classification of subjects as either spendthrift or thrifty is based on the median value of the adjusted decrease in 24EE from ENBAL during 24h fasting, such that thrifty subjects were identified as those with a greater-than-median decrease in adjusted 24EE (< −162 kcal/day). Abbreviations: 24EE, 24-h energy expenditure.