. 2020 Jul 7;3(7):e206004. doi: 10.1001/jamanetworkopen.2020.6004

Table 4. Risk Factors Associated With Mortality at 30 Days After Sepsis Diagnosis^a.

Variable^b	Total patients, No. (N = 1061)	Deaths, No.	Odds ratio (95% CI)	P value
Age group, y
18-44	166	24	1 [Reference]	NA
45-64	378	96	1.64 (0.96-2.80)	.07
65-84	384	109	1.96 (1.14-3.39)	.02
≥85	133	53	4.68 (2.51-8.76)	<.001
Sepsis-associated pathogen identified
Yes	605	148	1.21 (0.87-1.68)	.27
No	456	134	1 [Reference]	NA
Organ dysfunction^c
Yes	879	263	2.33 (1.35-4.04)	.003
No	182	19	1 [Reference]	NA
Septic shock^d
Yes	362	148	2.65 (1.93-3.65)	<.001
No	699	134	1 [Reference]	NA
Receipt of influenza or pneumococcal vaccine
Yes	493	124	1 [Reference]	NA
No	568	158	1.51 (1.10-2.06)	.01
Immunosuppression^e
Yes	280	111	2.52 (1.81-3.52)	<.001
No	781	171	1 [Reference]	NA
Cirrhosis
Yes	64	32	3.59 (2.03-6.32)	<.001
No	997	250	1 [Reference]	NA
Underlying vascular disease
Yes	323	109	1.54 (1.10-2.15)	.01
No	738	173	1 [Reference]	NA
Sepsis-associated infection documented at hospital discharge
No infection	317	102	1 [Reference]	NA
>1 infection	130	34	0.87 (0.52-1.46)	.61
Infection with source undetermined	28	12	1.62 (0.67-3.91)	.28
Type of infection
Abdominal^f	74	18	0.63 (0.34-1.19)	.15
Bloodstream	58	21	1.57 (0.80-3.09)	.18
Respiratory^g	239	62	0.81 (0.54-1.21)	.30
Skin and soft tissue	60	8	0.49 (0.21-1.14)	.10
Urinary tract	141	19	0.39 (0.22-0.71)	.002
Other^h	14	6	3.28 (0.98-11.02)	.05

Abbreviation: NA, not applicable.

^{^a}

Variable descriptions and reference levels are listed in eTable 2 in the Supplement.

^{^b}

Age group, septic shock, sepsis-associated pathogen, and presence of organ dysfunction were included in the model. A full list of variables is in eTable 2 in the Supplement.

^{^c}

Includes any of the following documented in the medical record within 7 calendar days of initial sepsis documentation: receipt of invasive mechanical ventilation or noninvasive positive pressure ventilation, receipt of vasopressor medication, systolic blood pressure level less than 90 mm Hg, or altered mental status.

^{^d}

Defined as 2 or more criteria of systemic inflammatory response syndrome plus the receipt of a vasopressor medication within 1 calendar day of sepsis diagnosis.

^{^e}

Includes steroid or immunosuppressive therapy, AIDS, hematologic malignancy, immunodeficiency or primary immunodeficiency, neutropenia, solid organ tumor with and without metastasis, history of bone marrow transplant, and history of solid organ transplant.

^{^f}

Includes any intra-abdominal, gastrointestinal tract, or hepatobiliary infection.

^{^g}

Includes lower respiratory infection and pneumonia.

^{^h}

Includes bone and joint infections; cardiovascular infections; infections of the ear, nose, or throat; central nervous system infections; disseminated viral infections; and infections of the reproductive tract.

Table 4. Risk Factors Associated With Mortality at 30 Days After Sepsis Diagnosisa.

Table 4. Risk Factors Associated With Mortality at 30 Days After Sepsis Diagnosis^a.