Table 2. Association Between Statin Use, All-Cause Mortality, and Major Cardiovascular Events in 326 981 US Veterans 75 Years and Older Free of Atherosclerotic Cardiovascular Disease at Baseline, After Propensity Score Overlap Weighting.
| Outcome | Crude rate/1000 person-years | Weighted incidence rate difference/1000 person-years (95% CI)a | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Statin user (N = 57 178) | Statin nonuser (N = 269 803) | ||||
| Primary outcomes | |||||
| All-cause mortality (n = 206 902) | 78.7 | 98.2 | −19.45 (−20.38 to −18.52) | 0.75 (0.74 to 0.76) | <.001 |
| All CV death (n = 53 296) | 22.6 | 25.7 | −3.09 (−3.63 to −2.55) | 0.80 (0.78 to 0.81) | <.001 |
| Secondary outcomes | |||||
| ASCVD composite (n = 123 379)b | 66.3 | 70.4 | −4.05 (−5.09 to −3.02) | 0.92 (0.91 to 0.94) | <.001 |
| Myocardial infarction (n = 24 951) | 13.2 | 12.6 | 0.56 (0.13 to 0.98) | 0.99 (0.97 to 1.03) | .94 |
| Ischemic stroke (n = 35 630) | 18.4 | 18.2 | 0.25 (−0.26 to 0.76) | 0.98 (0.96 to 1.01) | .20 |
| CABG surgery/PCI (n = 74 362) | 35.2 | 39.2 | −3.38 (−4.12 to −2.64) | 0.89 (0.88 to 0.91) | <.001 |
Abbreviations: ASCVD, atherosclerotic cardiovascular disease; CABG, coronary artery bypass graft; CV, cardiovascular; HR, hazard ratio; PCI, percutaneous coronary intervention.
a
Weighted incidence rate difference comparing statin users to nonusers after overlap weighting was applied.
b
ASCVD composite: time to first MI or ischemic stroke or CABG/PCI. There were fewer composite ASCVD events compared with total individual events, as participants were censored at first event of interest.