Table 3.
KEGG pathway enrichment analysis of genes of modules 1, 2, and 3 in the PPI network of GSE11792.
| Term | Description | Count | P value | Genes |
|---|---|---|---|---|
| Module 1 | ||||
| hsa01100 | Metabolic pathways | 12 | 5.21E-09 | SC5D, MSMO1, MVD, HMGCR, DHCR7, FDPS, HMGCS1, MVK, ACAT2, IDI1, NSDHL, FDFT1 |
| hsa01130 | Biosynthesis of antibiotics | 11 | 6.70E-15 | SC5D, MSMO1, MVD, HMGCR, FDPS, HMGCS1, MVK, ACAT2, IDI1, NSDHL, FDFT1 |
| hsa00900 | Terpenoid backbone biosynthesis | 7 | 2.32E-13 | MVD, HMGCR, FDPS, HMGCS1, MVK, ACAT2, IDI1 |
| hsa00100 | Steroid biosynthesis | 5 | 1.69E-08 | SC5D, MSMO1, DHCR7, NSDHL, FDFT1 |
| hsa00072 | Synthesis and degradation of ketone bodies | 2 | 0.015886 | HMGCS1, ACAT2 |
| hsa00650 | Butanoate metabolism | 2 | 0.042368 | HMGCS1, ACAT2 |
| Module 2 | ||||
| hsa04146 | Peroxisome | 9 | 3.18E-16 | ACOX2, PECR, AMACR, HAO2, GNPAT, IDH1, PEX13, CRAT, SLC27A2 |
| hsa00120 | Primary bile acid biosynthesis | 2 | 0.01961 | ACOX2, AMACR |
| Module 3 | ||||
| hsa00280 | Valine, leucine and isoleucine degradation | 6 | 7.14E-11 | ACAA2, DBT, ACADM, HADH, PCCB, ACAA1 |
| hsa01130 | Biosynthesis of antibiotics | 6 | 1.55E-07 | ACAA2, DBT, ACADM, HADH, PCCB, ACAA1 |
| hsa01100 | Metabolic pathways | 6 | 8.88E-04 | ACAA2, DBT, ACADM, HADH, PCCB, ACAA1 |
| hsa00071 | Fatty acid degradation | 4 | 4.18E-06 | ACAA2, ACADM, HADH, ACAA1 |
| hsa01212 | Fatty acid metabolism | 4 | 6.29E-06 | ACAA2, ACADM, HADH, ACAA1 |
| hsa00640 | Propanoate metabolism | 3 | 2.37E-04 | ACADM, ECHDC1, PCCB |
| hsa00062 | Fatty acid elongation | 2 | 0.021616 | ACAA2, HADH |
Notes: Count: the number of DEGs. Abbreviations: DEGs: differentially expressed genes; KEGG: Kyoto Encyclopedia of Genes and Genomes; PPI: protein–protein interaction.