Table 1.
Main characteristics of the included studies in the present meta-analysis.
| First author (year) | Country | Ethnicity | Control source | Type | Sample size | Case genotype | Control genotype | Genotyping method | NOS score | P(HWE) | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Case/control | TT | TG | GG | TT | TG | GG | ||||||||
| Blech (2011) | Israel | Caucasian | Diabetic | T2DM or T1DM | 852/1473 | 532 | 283 | 37 | 966 | 454 | 53 | PCR-RFLP | 7 | 0.999 |
| Choe (2013) | Korea | Asian | Diabetic | T2DM | 245/448 | 124 | 95 | 26 | 216 | 204 | 28 | SNaPShot | 7 | 0.083 |
| Chung (2014) | China | Asian | Diabetic | T2DM | 144/422 | 77 | 57 | 10 | 206 | 186 | 30 | Multiplex PCR | 8 | 0.386 |
| El-Shal (2014) | Egypt | African | Diabetic | T2DM | 196/100 | 53 | 113 | 30 | 64 | 32 | 4 | PCR-RFLP | 7 | 1 |
| Jaziri (2010) | France | Caucasian | Diabetic | T2DM | 75/3011 | 46 | 25 | 4 | 2223 | 728 | 60 | PCR-MB | 8 | 0.999 |
| Ma (2007) | Sweden | Caucasian | Diabetic | T1DM | 196/236 | 180 | 15 | 1 | 213 | 22 | 1 | PCR-DASH | 7 | 0.871 |
| Peng (2012) | China | Asian | Diabetic | T2DM | 42/40 | 25 | 14 | 3 | 19 | 18 | 3 | DS | 7 | 0.903 |
| Ranjbar (2011) | Iran | Caucasian | Diabetic | T2DM | 28/205 | 20 | 8 | 0 | 142 | 56 | 7 | PCR-RFLP | 7 | 0.880 |
| Rudofsky (2004) | Germany | Caucasian | Diabetic | T1DM | 73/166 | 47 | 26 | 147 | 19 | PCR-RFLP | 8 | N/A | ||
| Rudofsky (2004) | Germany | Caucasian | Diabetic | T2DM | 174/283 | 137 | 37 | 239 | 44 | PCR-RFLP | 8 | N/A | ||
| Sikka (2014) | India | Asian | Diabetic | T2DM | 145/152 | 124 | 20 | 1 | 128 | 22 | 2 | PCR-RFLP | 6 | 0.654 |
| Vionnet (2006) | Denmark | Caucasian | Diabetic | T1DM | 489/463 | 393 | 91 | 5 | 377 | 82 | 4 | Ampli-Fluor | 7 | 0.981 |
| Vionnet (2006) | Finland | Caucasian | Diabetic | T1DM | 387/469 | 349 | 37 | 1 | 416 | 51 | 2 | Ampli-Fluor | 7 | 0.949 |
| Vionnet (2006) | France | Caucasian | Diabetic | T1DM | 300/391 | 221 | 73 | 6 | 303 | 82 | 6 | Ampli-Fluor | 7 | 0.986 |
PCR: polymerase chain reaction; PCR-RFLP: PCR-restriction fragment length polymorphism; PCR-MB: PCR-molecular beacon; PCR-DASH: PCR-dynamic allele-specific hybridization; DS: Direct sequencing.