Table 2.
Meta-analysis of the association between the ADIPOQ rs2241766 polymorphism and DKD risk.
| Model | Ethnicity | Type | Total | No. of studies and participants | ||||
|---|---|---|---|---|---|---|---|---|
| Caucasian | Asian | African | T1DM | T2DM | T2DM or T1DM | |||
| GG vs. TT | ||||||||
| OR (95% CI) | 1.31 (0.92, 1.87) | 1.21 (0.78, 1.86) | 9.06 (3.00, 27.34) | 1.18 (0.54, 2.56) | 1.79 (1.26, 2.55) | 1.27 (0.82, 1.95) | 1.51 (1.16, 1.95) | 12 (324/7417) |
| Ph | 0.709 | 0.503 | / | 0.945 | 0.016 | / | 0.098 | |
| I2 test | 0.0% | 0.0% | / | 0.0% | 61.6% | / | 36.6% | |
| GG + TG vs. TT | ||||||||
| OR (95% CI) | 1.27 (1.01, 1.60) | 0.86 (0.69, 1.07) | 4.80 (2.86, 8.03) | 0.99 (0.80, 1.24) | 1.25 (0.81, 1.93) | 1.15 (0.96, 1.37) | 1.12 (0.90, 1.40) | 14 (3218/7987) |
| Ph | 0.006 | 0.864 | / | 0.312 | 0.000 | / | 0.000 | |
| I2 test | 62.9% | 0.0% | / | 16.1% | 83.0% | / | 72.9% | |
| GG vs. TT+TG | ||||||||
| OR (95% CI) | 1.26 (0.88, 1.79) | 1.34 (0.88, 2.03) | 4.34 (1.48, 12.68) | 1.15 (0.53, 2.50) | 1.68 (1.18, 2.39) | 1.22 (0.79, 1.87) | 1.43 (1.11, 1.85) | 12 (324/10185) |
| Ph | 0.800 | 0.483 | / | 0.955 | 0.229 | / | 0.537 | |
| I2 test | 0.0% | 0.0% | / | 0.0% | 26.1% | / | 0.0% | |
| G vs. T | ||||||||
| OR (95% CI) | 1.12 (1.01, 1.25) | 0.95 (0.80, 1.14) | 3.16 (2.12, 4.71) | 1.05 (0.87, 1.26) | 1.19 (0.81, 1.75) | 1.13 (0.97, 1.31) | 1.13 (0.93, 1.38) | 12 (3416/17602) |
| Ph | 0.245 | 0.690 | / | 0.540 | 0.000 | / | 0.000 | |
| I2 test | 24.1% | 0.0% | / | 0.0% | 82.8% | / | 71.4% | |
| TG vs. TT | ||||||||
| OR (95% CI) | 1.12 (0.98, 1.27) | 0.81 (0.65, 1.02) | 4.26 (2.50, 7.28) | 1.04 (0.85, 1.27) | 1.18 (0.72, 1.91) | 1.13 (0.94, 1.36) | 1.11 (0.88, 1.40) | 12 (1937/5273) |
| Ph | 0.547 | 0.885 | / | 0.580 | 0.000 | / | 0.000 | |
| I2 test | 0.0% | 0.0% | / | 0.0% | 82.7% | / | 70.3% | |
Note: Ph: p value of heterogeneity; if Ph is >0.05, a fixed-effect model was used to calculate OR and 95% CI; otherwise, a random-effect model was used.