Table 2.
Effect of combination treatment between artesunate and kaempferol on mean survival time of Plasmodium berghei ANKA-infected mice.
Test | Dose | MST (days) |
---|---|---|
Untreated | 10 ml/kg | 8.2 ± 1.9 |
| ||
KMF | 1 mg/kg | 10.2 ± 1.3 |
5 mg/kg | 14.4 ± 1.9∗ | |
20 mg/kg | 22.8 ± 1.9∗∗∗ | |
100 mg/kg | 33.6 ± 4.0∗∗∗ | |
| ||
ART | 1 mg/kg | 14.6 ± 1.8∗ |
3 mg/kg | 17.6 ± 2.1∗∗∗ | |
10 mg/kg | 28.4 ± 2.9∗∗∗ | |
30 mg/kg | 51.2 ± 4.1∗∗∗ | |
| ||
Combination (1 : 1) | ED50 (20KMF + 6ART) | 51.8 ± 2.2∗∗∗,a |
ED50 1/2 (10KMF + 3ART) | 43.0 ± 2.1∗∗∗,a | |
ED50 1/4 (5KMF + 1.5ART) | 9.4 ± 1.7 | |
ED50 1/8 (2.5KMF + 0.75ART) | 9.0 ± 1.6 |
∗∗∗ P < 0.001, compared to the untreated group. aP < 0.001, compared to 10 mg/kg of ART.