Table 2.

Effect of combination treatment between artesunate and kaempferol on mean survival time of Plasmodium berghei ANKA-infected mice.

Test	Dose	MST (days)
Untreated	10 ml/kg	8.2 ± 1.9
KMF	1 mg/kg	10.2 ± 1.3
	5 mg/kg	14.4 ± 1.9∗
	20 mg/kg	22.8 ± 1.9∗∗∗
	100 mg/kg	33.6 ± 4.0∗∗∗
ART	1 mg/kg	14.6 ± 1.8∗
	3 mg/kg	17.6 ± 2.1∗∗∗
	10 mg/kg	28.4 ± 2.9∗∗∗
	30 mg/kg	51.2 ± 4.1∗∗∗
Combination (1 : 1)	ED50 (20KMF + 6ART)	51.8 ± 2.2∗∗∗,a
	ED50 1/2 (10KMF + 3ART)	43.0 ± 2.1∗∗∗,a
	ED50 1/4 (5KMF + 1.5ART)	9.4 ± 1.7
	ED50 1/8 (2.5KMF + 0.75ART)	9.0 ± 1.6

^∗∗∗ P < 0.001, compared to the untreated group. ^aP < 0.001, compared to 10 mg/kg of ART.